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Trans-dentinal Stimulation of Tertiary Dentinogenesis

Oral Biology, School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK, a.j.smith{at}bham.ac.uk

P.E. Murray

Oral Biology, School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK

A.J. Sloan

Oral Biology, School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK

J.B. Matthews

Oral Biology, School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK

S. Zhao

QinDu Faculty of Stomatology, FMMU, Xi'an Shaanxi, People's Republic of China

Trans-dentinal stimulation of tertiary dentinogenesis has long been recognized, and has traditionally been ascribed to diffusion of irritant substances arising during injury and restorative treatment. Identification of bio-active components, especially growth factors including TGF-βs, sequestered within dentin matrix provides a new explanation for cellular signaling during tertiary dentinogenesis. Both isolated dentin matrix components and pure growth factors (TGF-βs) have been shown to signal cellular events leading to reactionary and reparative tertiary dentinogenesis. Release of these bio-active components from dentin matrix may arise during carious attack and other injury to the tissue, and also during subsequent surgical intervention and restoration of the tooth. Both cavity-conditioning agents and leaching from restorative materials may contribute to release of these components. Distance of diffusion, as determined by cavity residual dentin thickness, and other restorative parameters may influence the signaling process after release of these components. Careful consideration of the interplay between tissue injury and surgical and restorative material factors is required for optimum exploitation of the exquisite regenerative capacity of dentin-pulp for more biological approaches to clinical treatment of dental disease.

Key Words: Odontoblast • dentin • growth factor • tertiary dentinogenesis.

Advances in Dental Research, Vol. 15, No. 1, 51-54 (2001)
DOI: 10.1177/08959374010150011301


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