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Advances in Dental Research
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Adv Dent Res 15:105-107, August, 2001
© 2001 SAGE Publications

Enamel Matrix Derivative Promotes Reparative Processes in the Dental Pulp

Y. Nakamura

Department of Endodontics, School of Dentistry, Showa University, 2-1-1, Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan

L. Hammarström

Center for Oral Biology, School of Dentistry, Karolinska Institutet, PO Box 4064, S-14 104 Huddinge, Sweden

E. Lundberg

Biora AB, Medeon Science Park, Malmö, S-205 12, Malmö, Sweden

H. Ekdahl

Biora AB, Medeon Science Park, Malmö, S-205 12, Malmö, Sweden

K. Matsumoto

Department of Endodontics, School of Dentistry, Showa University, 2-1-1, Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan

S. Gestrelius

Biora AB, Medeon Science Park, Malmö, S-205 12, Malmö, Sweden

S.P. Lyngstadaas

Biora AB, Medeon Science Park, Malmö, S-205 12, Malmö, Sweden, Clinical Research Laboratory, Faculty of Dentistry, University of Oslo, PO Box 1109, Blindern, N-0317 Oslo, Norway, petter.lyngstadaas{at}biora.com

During odontogenesis, amelogenins from the preameloblasts are translocated to differentiating odontoblasts in the dental papilla, suggesting that amelogenins may be associated with odontoblast changes during development. In the present study, we have explored the effects of enamel matrix derivative (EMD) on the healing of a pulpal wound. Coronal pulp tissue of permanent maxillary premolars of miniature swine were exposed through buccal class V cavities. The exposed pulp was capped with EMD. The contralateral teeth served as controls and were capped with a calcium hydroxide paste (Dycal®). The cavities were sealed with glass-ionomer cement. After 2 and 4 weeks, the histology of the teeth was analyzed. In the EMD-treated teeth, large amounts of newly formed dentin-like hard tissue with associated formative cells outlined the pulpal wound separating the cavity area from the remaining pulp tissue. Inflammatory cells were present in the wound area but not subjacent to the newly formed hard tissue. Morphometric analysis showed that the amount of hard tissue formed in EMD-treated teeth was more than twice that of the calcium-hydroxide-treated control teeth (p < 0.001), suggesting that EMD is capable of promoting reparative processes in the wounded pulp more strongly than is calcium hydroxide.

Key Words: Dental pulp • dentinogenesis • enamel matrix derivative • pulpal wound healing.

Advances in Dental Research, Vol. 15, No. 1, 105-107 (2001)
DOI: 10.1177/08959374010150010201
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